Dr. Meghna Singh
- Assistant Professor
- A researcher and academician having over a decade of experience in Molecular Biology and Genetic Engineering. My research interests are in vaccine candidate characterization and immune profiling of antigens in human infective diseases.
- Central Drug Research Institute, Lucknow (registration under Jawaharlal Nehru University, New Delhi)
- PhD in Biotechnology (2010)
- Topic: Molecular cloning and characterization of functional antigen/s of infective larvae of human lymphatic filariid Brugia malayi
- Chaudhary Charan Singh University, Meerut
- MSc in Biotechnology
- Post Doctoral Fellow 2010-2012
- Dept of Biosciences and Bioengineering, IIT Bombay.
- Awarded DBT Post-doctoral Fellowship for project “Low molecular weight proteome analysis of human malaria parasite Plasmodium falciparum” in the Molecular Parasitology. Laboratory of Prof. Swati Patankar. The objective of the project was to identify low molecular weight proteins and study their role in gene expression regulation of malaria parasite Plasmodium facliparum.
- Role-Micro-management of project and ensure smooth delivery of results. Decision-making in coordination with lab supervisor for experiments and project driving. Analysis of generated data, report preparation and presentation of work to scientific/non-scientific audiences.
- DST SERB-TARE (Government of India) Research Grant: Ongoing
- Project entitled- “PfSEA1 antigen characterization as potential vaccine candidate against human malaria parasite Plasmodium falciparum” The research project outlay is ₹ 15 lakhs over a period of 3 years and aims at expression and characterization of a novel antigen of malaria parasite. The antigen shows strong immunogenicity against the parasite in the human host. Further studies on the egress antigen would help to design an effective vaccine against the morbid parasite.
Areas of Interests
- Molecular Immunology, Human infective pathogens, Host-Parasite Relationship
Research publications in International Journal
1. Singh Meghna, Soni V.K, Dangi A, Kumar N and Bhattacharya S. (2006) Piper Betel-The female plant stimulates immune functions in mice. International conference on ‘Advances in Drug Discovery Research’ Feb-2006, Aurangabad (India).
2. Singh Meghna, Srivastava K.K and Bhattacharya S. (2007) Molecular cloning and characterization of ATP dependent RNA Helicase in human filarial parasite Brugia malayi. In 89th Session of Indian Science Congress, Dec-2007 at Lucknow University, Lucknow, India.
3. Meghna Singh, K. K. Srivastava, Shailja M (2008) Bhattacharya. Molecular cloning and characterization of a novel immunoreactive ATPase/RNA Helicase in Human Filarial parasite Brugia malayi. Parasitol
Res, 104 (4):753-761.3
4. Singh Meghna and Bhattacharya S. (2008) Silencing effects of ATP dependent RNA Helicase in human filarial parasite Brugia malayi using RNAi. Satellite Meeting to 13th Human Genome Organization conference, October 1-2, 2008, “Genomics, Model Organism and Disease”.
5. Meghna Singh, Shilpy Shakya, Vishal K Soni, Anil Dangi, Nikhil Kumar, Shailja Misra-Bhattcharya (2009)
The n-Hexane and Chloroform fractions of Piper betle L. trigger different arms of immune responses in BALB/c mice. Int Immunopharmacol, 9(6):716-728.
6. Meghna Singh, Prashant Kumar Singh, Shailja Misra-Bhattacharya (2012) RNAi mediated silencing of ATPase RNA helicase gene in adult filarial parasite Brugia malayi impairs in vitro microfilaria release and adult parasite viability. Journal of Biotechnology 157, 351–358.
7. Aishwarya Narayan, Mayan Kumar, Meghna Singh, Prasad Babar, Rahul Chaudhuri, Swati Patankar (2012) Regulation of gene expression in Plasmodium falciparum. Current Science special malaria edition (Invited Review), 102(4).
8. Meghna Singh, Nidhi Shrivastava, Uzma Saqib, Mohammad Imran Siddiqi, Shailja Misra-Bhattacharya (2013). Structural modeling studies and immunoprophylactic potential of Brugia malayi DEAD Box RNA helicase. Parasitology 2013 Jul;140(8):1016-25.
Research projects undertaken
DST SERB-TARE (Government of India) Research Grant: Ongoing
Project entitled- “PfSEA1 antigen characterization as potential vaccine candidate against human malaria parasite Plasmodium falciparum”
The research project outlay is ? 15 lakhs over a period of 3 years and aims at expression and characterization of a novel antigen of malaria parasite.
The antigen shows strong immunogenicity against the parasite in human host. Further studies on the egress antigen would help to design an effective vaccine against the morbid parasite.
Awards & Honors
- Awarded Post Doctoral Fellowship (July’ 2010-2012) by Department of Biotechnology (DBT), New Delhi
- Senior Research Fellowship (Sept 2007 –June 2010): from University Grants Commission, New Delhi.
- Junior Research Fellowship (Sept 2005 – Sept 2007): from University Grants Commission, New Delhi
- NET-JRF Qualified
- GATE Qualified
- Editor Member of National Journal Vivechan (J-GATE Indexed) (http://www.ijrimsec.com)
- Member of Indian Academy of Science